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252604

Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Rose is one of the most important ornamental plants, with economic and cultural importance. In this work, the methanol extract of Taif rose (Rosa damascena trigintipetala Dieck) was investigated for its toxicity (Acute, Sub-chronic and Chronic) and long-term side effects. Also, the effect of dose accumulation on physiological parameters and histopathological changes in normal mice was studied. The results of this study showed that no toxicity indication of methanol extract of Taif rose during acute, sub-chronic and chronic periods on physiological parameters while the pathological studies showed minimal changes in the vital organs. From this work, it is clear that Taif rose methanol extract could be utilised as a good natural, affordable, and safe therapy.

DOI

10.21608/ejchem.2022.146123.6358

Keywords

Taif Rose, methanol extract, Acute, sub-chronic, chronic toxicity, Mice

Authors

First Name

Abdel-Nasser

Last Name

Sabra

MiddleName

-

Affiliation

Pharmacology Department, Theodor Bilharz Research Institute, Kornish El-Nile-Warrak El-Hadar, Imbaba, Giza 12411, Egypt.

Email

abdelnassersabraa@yahoo.com

City

Cairo

Orcid

-

First Name

Salih

Last Name

Bazaid

MiddleName

-

Affiliation

College of Sciences, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia

Email

prof_sbazaid@yahoo.com

City

Taif

Orcid

-

First Name

El sayed

Last Name

Saleh

MiddleName

-

Affiliation

Medicinal Chemistry Lab., Theodor Bilharz Research Institute, Giza, Egypt

Email

shzssayed@yahoo.com

City

-

Orcid

0000-0002-0482-2170

Volume

66

Article Issue

4

Related Issue

40820

Issue Date

2023-04-01

Receive Date

2022-06-21

Publish Date

2023-04-01

Page Start

253

Page End

264

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_252604.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=252604

Order

252,604

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Details

Type

Article

Created At

30 Dec 2024