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248911

Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.

DOI

10.21608/ejchem.2022.147813.6399

Keywords

Malonic hydrazide, Azines, Azoles, condensed system, polythiourea

Authors

First Name

Mohamed

Last Name

Abd El-Azim

MiddleName

H

Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, Egypt.

Email

drmhm1982@gmail.com

City

-

Orcid

-

First Name

mohammed

Last Name

assy

MiddleName

gomma

Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, (Egypt)

Email

m_gomaa59@yahoo.com

City

zagazig

Orcid

-

First Name

Maha

Last Name

Elmesalamy

MiddleName

Ahmed

Affiliation

Department of Chemistry - Zagazig University - Zagazig- Egypt

Email

dr.maha198907@gmail.com

City

-

Orcid

-

First Name

Yasser

Last Name

Selim

MiddleName

-

Affiliation

Chemistry Department, Faculty of Specific Education. Zagazig University

Email

y2selem@yahoo.com

City

-

Orcid

0000-0002-5846-9069

Volume

66

Article Issue

3

Related Issue

40217

Issue Date

2023-03-01

Receive Date

2022-06-28

Publish Date

2023-03-01

Page Start

479

Page End

482

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 3_Pages 479-482.pdf

PDF . 384.3kB

Link

https://ejchem.journals.ekb.eg/article_248911.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=248911

Order

248,911

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Details

Type

Article

Created At

30 Dec 2024