Beta
ManageSearchChatDiscover
246755

First- and Second-Derivative Spectrophotometry for Simultaneous Determination of lorazepam and clonazepam in pharmaceutical formulations.

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Analytical chemistry

Abstract

The present study describes employing zero-, 1st - and 2nd -order derivative spectrophotometric methods have been developed for determination of lorazepam (LORA) and clonazepam (CLON) in commercially available tablets. LORA was determined by means of 1st (D1), 2nd (D2) derivative spectrophotometric techniques using zero cross, peak height, and Peak area. D1 used for the determination of CLON by using zero cross and peak height while D2 (zero cross) was used for the determination of CLON. The method was established to be linear in concentration containing different ratios of LORA and CLON range of (20-200 mg/L) and (5-35 mg/L) at wavelength range (250 -370 nm), (210-370nm) respectively. The proposed techniques are highly sensitive, precise and accurate and can be used for the reliable quantitation of lorazepam and clonazepam in tablet formulation

DOI

10.21608/ejchem.2022.130646.5753

Keywords

first- and second derivative spectroscopy, lorazepam, Clonazepam

Authors

First Name

Faeza

Last Name

Zankanah

MiddleName

H.

Affiliation

College of Health & Medical Technology, Uruk University, Baghdad-Iraq.

Email

dr.faizahazem@uruk.edu.iq

City

Baghdad

Orcid

-

First Name

Fatma

Last Name

Al Ani

MiddleName

A. A.

Affiliation

Department of Chemistry, College of Education for Pure Science/ Ibn Al-Haitham, Adhamiya, University of Baghdad, Baghdad-Iraq.

Email

fatma.a.aj@ihcoedu.uobaghdad.edu.iq

City

-

Orcid

-

First Name

Ala'a

Last Name

Shaker

MiddleName

R.

Affiliation

College of Health & Medical Technology, Uruk University, Baghdad-Iraq.

Email

alaarazaq@uruk.edu.iq

City

-

Orcid

-

First Name

Ahmed

Last Name

Taha

MiddleName

b.

Affiliation

College of Health & Medical Technology, Uruk University, Baghdad-Iraq.

Email

ahmedtaha@uruk.edu.iq

City

-

Orcid

-

First Name

Mohammed

Last Name

Abdulraheem

MiddleName

S.

Affiliation

Ministry of Education, Baghdad College, Baghdad-Iraq.

Email

mohemad.salah22@gmail.com

City

-

Orcid

-

Volume

66

Article Issue

3

Related Issue

40217

Issue Date

2023-03-01

Receive Date

2022-03-30

Publish Date

2023-03-01

Page Start

271

Page End

280

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 3_Pages 271-280.pdf

PDF . 1.4MB

Link

https://ejchem.journals.ekb.eg/article_246755.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=246755

Order

246,755

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

First- and Second-Derivative Spectrophotometry for Simultaneous Determination of lorazepam and clonazepam in pharmaceutical formulations.

Details

Type

Article

Created At

30 Dec 2024