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Curcumin Ameliorates Acrylamide Induced Ovarian Toxicity in Albino Female Rats: A Biochemical and Histological Study

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Last updated: 01 Jan 2025

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Abstract

Acrylamide (AA), an industrial compound, causes reproductive toxicity in female rats due to oxidative stress. In the present study, we investigated the protective effects of Curcumin (Cur) against acrylamide-induced ovarian toxicity in female rats. The animals utilized in this study were divided into 4 groups: GI- Control group received a daily oral administration of 0.5ml DMSO (5%) saline(9%), GII- Acrylamide (AA) group received acrylamide (20 mg/kg b.w.) for 21days, GIII- Acrylamide + Curcumin (AA + Cur) group treated with Curcumin (100 mg/kg b.w.) after acrylamide intoxication for 21 days, GIV- Curcumin (Cur) group that received only Curcumin (100 mg/kg b.w.). In our study, we observed acrylamide intoxication to be associated with a significant (P<0.05) increase in the serum levels of estradiol, luteinizing hormone (LH), testosterone (T), and tumor marker CA125 and CEA. The mean values of serum progesterone (P4), follicle-stimulating hormone (FSH), and total antioxidant capacity (TAC) significantly decreased in the AA treated group as compared to the control. Histological investigations revealed that AA treatment results in an apparent regression of ovarian follicles, cyst formation, and corpus luteum degeneration. Treatment with curcumin restored altered ovarian histology and serological indices concomitantly towards normal

DOI

10.21608/ejchem.2022.139554.6136

Keywords

Keywords: Reproductive, female toxicity, acrylamide, Curcumin

Authors

First Name

Nagwa M

Last Name

Elsawi

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Affiliation

Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

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hamde_r2001@yahoo.com

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First Name

Shymaa A. Th.

Last Name

Abo Kresha

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Affiliation

Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

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First Name

Mounir A. A.

Last Name

Mohamed

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Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

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First Name

Ahmed

Last Name

Khorshed

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-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt

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ahmed_khorshed@pharm.sohag.edu.eg

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-

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First Name

Wejdan, A.

Last Name

Aldajani

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Affiliation

Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 2155, Saudi Arabia

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First Name

Nisreen Abdullah

Last Name

Rajeh

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-

Affiliation

Anatomy Department, medical college, KAU, Jeddah 2155, Saudi Arabia

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First Name

Nada A.

Last Name

El-Shahawy

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Affiliation

Institute of Animal Production Research, Dokki, Giza, Egypt

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Orcid

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First Name

Soad

Last Name

Ali

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-

Affiliation

Yousef Abdul Latif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia , Department of Histology and Cell Biology, Faculty of Medicine, Assuit University, Assuit 98467, Egypt

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Volume

66

Article Issue

3

Related Issue

40217

Issue Date

2023-03-01

Receive Date

2022-05-21

Publish Date

2023-03-01

Page Start

157

Page End

168

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 3_Pages 157-168.pdf

PDF . 693.5kB

Link

https://ejchem.journals.ekb.eg/article_287859.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=287859

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287,859

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Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Curcumin Ameliorates Acrylamide Induced Ovarian Toxicity in Albino Female Rats: A Biochemical and Histological Study

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Article

Created At

30 Dec 2024