Gout is a chronic disease that usually affects male adults and is more susceptible to it, and it is rare in children. The current study aimed to determine the level of lead bioaccumulation and its effect on some biochemical parameters in the blood serum of gout patients. The current study involved 70 patients (38 males & 32 females), whose ages range (20-60) years, after the disease was diagnosed by specialist doctors of Arthritis in city of Mosul, 40 healthy (20 males and 20 females) of the same age , was considered as a control group for comparison.

The results of this study showed a significant increase in the level of accumulated lead in the serum of patients in both sexes, compared with healthy controls, if the ratio of lead in males was 158% higher than in females. The results also showed a significant increase in level of each of uric acid, creatinine, urea and sodium, and the ratio of high level of these parameters was higher in males than in females but associated with a significant decrease in level of potassium in the blood serum of patients in both sexes, compared with healthy controls. We conclude from this study that continuous exposure to lead and its accumulation may cause a defect in kidney functions in patients with gout.