The present work involves The new bis-chalcones of 3-acetylcoumarin are synthesized by reaction with (terephthaldehyde and isophthalaldehyde) followed by condensation of these chalcones with some compounds (hydroxylamine, aminophenol, phenylenediamine, hydrazine, semicarbazide, thiosemicarbazide, urea, thiourea and quanidine) as precursor to form Isoxazole, oxazepane, diazepine, pyrazoles and pyrimidine derivatives (1-3k) in basic media using classical and ultrasonic technique. The comparison of the classical methods with ultrasonic methods was achieved .The structures of synthesized compounds were confirmed by FT-IR and 1H NMR spectroscopy.