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240038

Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Novel 6-(1H-1,2,3-triazol-4-yl)-imidazo[2,1-b]thiazoles 8-10 were synthesized in good yields by Claisen–Schmidt reaction of the active methylene compounds such as pyrazol-5-one 5, 1,3-indandione 6 and benzoylaceteonitrile 7, with imidazo[2,1-b]thiazol-5-aldehydes 4 in basic medium. Anti-tumor activities in vitro against HepG-2, PC-3 and HCT-116 human carcinoma cell lines were tested for new products. Both compounds 9a and 9b showed antitumor activity comparable to that of positive control (Doxorubicin®). Also, the antimicrobial activities of novel compounds were evaluated. Amongst the tested compounds 9a, 9b, and 10 exhibited excellent antimicrobial activity.

DOI

10.21608/ejchem.2022.138240.6078

Keywords

1,2,3-Triazole, Anticancer, Antimicrobial activity, Single crystal x-ray

Authors

First Name

Bakr

Last Name

Abdel-Wahabb

MiddleName

F

Affiliation

Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Center, Dokki, Giza, 12622 Egypt

Email

bf.fathy@nrc.sci.eg

City

-

Orcid

-

First Name

Hanem

Last Name

Awad

MiddleName

-

Affiliation

Tanning Materials and Leather Technology Department, National Research Centre, Egypt

Email

hanem_awad@yahoo.com

City

-

Orcid

0000-0002-3970-2371

First Name

Ghada

Last Name

Awad

MiddleName

-

Affiliation

Pharmaceutical and Drug Industries Research division

Email

ghadaawad18@yahoo.com

City

-

Orcid

-

First Name

Hanan

Last Name

Mohamed

MiddleName

M

Affiliation

Applied organic chemistry Department; National Research Centre; Egypt

Email

hananm_2004@yahoo.com

City

-

Orcid

-

Volume

66

Article Issue

2

Related Issue

39241

Issue Date

2023-02-01

Receive Date

2022-05-13

Publish Date

2023-02-01

Page Start

223

Page End

230

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 2_Pages 223-230.pdf

PDF . 798.0kB

Link

https://ejchem.journals.ekb.eg/article_240038.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=240038

Order

240,038

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles

Details

Type

Article

Created At

30 Dec 2024