Drug addiction is a chronic, recurrent mental illness marked by compulsive drug seeking despite grave adverse effects. Methamphetamine is a member of the synthetic drug class known as amphetamine-type stimulants, a class of medications that stimulate or create alertness and behavioural activation as well as increased central nervous system activity. Oxidative stress is a condition when there is an imbalance between the generation of free radicals and the capacity of the biological system to detoxify the reactive intermediates by neutralising antioxidants. METH causes a significant increase in the oxidation of dopamine(DA), which results in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). The body is protected by antioxidants, which can lessen ROS/RNS damage. By preventing reactive radicals from forming or by halting free radical reactions, the protective system's function may reduce the harmful consequences of free radicals. The goal of the current review was to draw attention to the impact of drug addiction (namely, methamphetamine) on oxidative stress in humans and the value of employing natural antioxidants to mitigate the harm that results. As a result of drug misuse, including methamphetamine usage, neuronal damage result from oxidative stress within mitochondrial membrane and dopamine pathway. Vitamin C, E, and other natural compounds have been found as being particularly promising in terms of their effects and safety.