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290207

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Antibacterial agents structurally based on quinazolin-4-one pharmacophore, have been designed and synthesized. Where the targeted compounds 5a, c and 6a-c were in vitro screened against three gram positive and three gram negative bacteria strains compared to ciprofloxacin as reference drug. Most of compounds had moderate antibacterial activity while compound 5c showed the most significant activity and could be considered as a new lead compound for antibacterial drug design.

DOI

10.21608/ejchem.2023.14892.1905

Keywords

Quinazolinone, Antibacterial

Authors

First Name

Aya

Last Name

Emam

MiddleName

M.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt

Email

ayaemam35@yahoo.com

City

-

Orcid

-

First Name

Hend

Last Name

Kothayer

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt

Email

hendo1311@hotmail.com

City

-

Orcid

-

First Name

Samy

Last Name

Ibrahim

MiddleName

M.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.

Email

dr-samy2010@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Sadek

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.

Email

m.elhussenyelsadek@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

132

Related Issue

39238

Issue Date

2022-12-01

Receive Date

2019-07-17

Publish Date

2022-12-01

Page Start

1,547

Page End

1,551

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 132_Pages 1547-1551.pdf

PDF . 523.9kB

Link

https://ejchem.journals.ekb.eg/article_290207.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=290207

Order

290,207

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Details

Type

Article

Created At

30 Dec 2024