Beta
ManageSearchChatDiscover
249604

Anticancer effect of Sorafenib-loaded iron oxide nanoparticles and bee venom on some genes expression in hepatocellular carcinoma

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

ObjectiveSuperparamagnetic iron oxide@silver@chitosan core-shell nanoparticles could be a promising anticancer agent. This experiment was designed to compare bee venom, a natural substance that has been utilized as a traditional medicine for the treatment of cancer, to a new strategy in the recession of hepatocellular carcinoma utilizing Fe2O3@Ag@Cs nanoparticles. Methods: Group I is the negative control group, and Group II is the positive control group. The positive control group received a single intraperitoneal injection of 60 mg/kg b.wt. diethyl nitrosamine, followed by two days of carbon tetrachloride diluted with paraffin oil.Group III was given sorafenib twice a week by gavage for one month, Group IV was given Fe2O3@Ag@Cs core shell NPs, Group V was given Fe2O3@Ag@Cs core shell NPs loaded with sorafenib, and Group VI was given bee venom. Results:In comparison between the treated groups and the positive control group, biochemical data demonstrated a highly significant drop in ALT, AST, ALP, and AFP after treatment, as well as significant down-regulation in the DTL gene, while DUSP1, SOCS2, and NFKB1A exhibited up-regulation after treatment.Conclusion:Because there was a significant variation in the fold of expression in studied genes, which related to the degree of pathogenicity of hepatocellular carcinoma and gave good valuable insights about the progression of HCC and prognosis, loading sorafenib on Fe2O3@Ag@Cs core-shell NPs is superior to bee venom in the treatment of hepatocellular carcinoma.

DOI

10.21608/ejchem.2022.138553.6104

Keywords

Hepatocellular carcinoma, Bee venom, Sorafenib, Drug delivery, γ Fe2O3@Ag@Cscore shell NPs

Authors

First Name

Rana

Last Name

A. A. Nagy

MiddleName

-

Affiliation

Biochemistry faculty of science Cairo university .

Email

rana_assem@yahoo.com

City

-

Orcid

0000-0003-4472-0475

First Name

Heba

Last Name

K.A. Elhakim

MiddleName

-

Affiliation

Biochemistry, faculty of Science, Cairo university, Giza, Egypt

Email

drheba_76@yahoo.com

City

-

Orcid

-

First Name

mona

Last Name

mohamed

MiddleName

hassan

Affiliation

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

mona_hassan116@yahoo.com

City

egypt

Orcid

-

First Name

Mie

Last Name

afify

MiddleName

-

Affiliation

Department of Biochemistry, Biotechnology Research Institute, National Research Centre, Dokki, Giza

Email

mieafify@yahoo.com

City

-

Orcid

0000-0002-3187-1322

First Name

Mohamed

Last Name

D.E. Abd El-Maksoud

MiddleName

-

Affiliation

Biochemistry department, Biotechnology Research Institute, National Research Centre, Dokki, Giza

Email

dr_mohameddiaa1965@yahoo.com

City

cairo

Orcid

0000-0002-9312-0807

First Name

abd el razik

Last Name

mohamed

MiddleName

farrag

Affiliation

Professor of Histology and Histochemistry, Pathology Department, Medical Research Division, National Research Centre, Dokki, Giza, 12622, Egypt

Email

abdelrazik232@yahoo.com

City

egypt

Orcid

-

First Name

Doaa

Last Name

S. R. Khafaga

MiddleName

-

Affiliation

1 Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt 2 Faculty of Medicine, Galala University, Suez, 43511, Egypt

Email

doaasayed473@yahoo.com

City

Egypt

Orcid

0000-0002-0576-0100

First Name

May

Last Name

Eid

MiddleName

M.

Affiliation

Spectroscopy Department, National Research Centre, Dokki, Giza, 12622, Egypt

Email

maybaker25@gmail.com

City

Giza

Orcid

-

Volume

65

Article Issue

132

Related Issue

39238

Issue Date

2022-12-01

Receive Date

2022-05-16

Publish Date

2022-12-01

Page Start

1,477

Page End

1,487

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 132_Pages 1477-1487.pdf

PDF . 634.4kB

Link

https://ejchem.journals.ekb.eg/article_249604.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=249604

Order

249,604

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Anticancer effect of Sorafenib-loaded iron oxide nanoparticles and bee venom on some genes expression in hepatocellular carcinoma

Details

Type

Article

Created At

30 Dec 2024