Beta
ManageSearchChatDiscover
260171

Design, Synthesis, and biological evaluation of a novel series of thiazole derivatives based on pyrazoline as anticancer agents

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

This study deals with the design and synthesis of new pyrazoline-thiazole scaffold as promising anti-cancer agents, with the goal of building new compounds with combinations of various heterocyclic moieties. The pyrazoline-thiazole scaffold was synthesized via cyclization of the chalcone derivatives with thiosemicarbazide to afford the corresponding thioamide 5, which was the key precursor for synthesis of the compounds 7-15. Three cancer cell lines (MCF-7, HepG-2 and A549) were used to examine in vitro anticancer activities of the recently synthesized compounds. Three compounds 7c, 9c, and 11d were found to show the most promising anti-cancer activity against three cell lines.

DOI

10.21608/ejchem.2022.157866.6848

Keywords

Chalcone, thioamide, Pyrazoline, thiazole, haloketone, anti-cancer agent

Authors

First Name

Usama

Last Name

Fathy

MiddleName

-

Affiliation

Applied Organic Chemistry depatment

Email

usamafathy06@gmail.com

City

-

Orcid

0000-0002-0821-5271

First Name

Mahmoud

Last Name

Yousif

MiddleName

Nabil Mahmoud

Affiliation

Department of Photochemistry, National Research Centre, Cairo, Egypt

Email

mahmoud_nabil18@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Mohi El-Deen

MiddleName

M.

Affiliation

Therapeutic Chemistry Department, National Research Centre, Cairo, Egypt.

Email

e.mohi.2010@live.com

City

-

Orcid

orcid.org/0000-0002-1997-3254

First Name

Eman

Last Name

Fayed

MiddleName

-

Affiliation

4Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11754, Egypt

Email

alfayed_e@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

132

Related Issue

39238

Issue Date

2022-12-01

Receive Date

2022-08-24

Publish Date

2022-12-01

Page Start

1,241

Page End

1,252

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 132_Pages 1241-1252.pdf

PDF . 607.7kB

Link

https://ejchem.journals.ekb.eg/article_260171.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=260171

Order

260,171

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Design, Synthesis, and biological evaluation of a novel series of thiazole derivatives based on pyrazoline as anticancer agents

Details

Type

Article

Created At

30 Dec 2024