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Algerian Capparis spinosa n-BuOH Extract Alleviates Diabetic Neuropathy Induced with Streptozotocin in Rats

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Last updated: 01 Jan 2025

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Abstract

Diabetic neuropathy (DN) is the most common diabetes complication. This study aimed to investigate the possible neuroprotective effects of the n-BuOH extract of Capparis spinosa (BECS) against DM-neuropathy induced with streptozotocin (STZ) and explore its phytoconstituents. From our results, BECS showed no toxicity against C6 brain cancer cell lines. The treatment of male Swiss albino rats with BECS (200 mg/kg) for a period of 28 days significantly attenuated the adverse effects of STZ-induced diabetes (60 mg/kg). A decrease in blood glucose was noted in the BECS-STZ group, associated with a significant (p<0.01) improvement in serum and brain insulin levels. The BECS- treated group showed a significant (p<0.01) improvement in serum C-peptide, serum AGE and serum CK-BB levels. BECS was also successful in restricting HbA1c in STZ-treated rats. Furthermore, a resurrection of neuronal membrane integrity was manifested in the BECS+STZ group, as evidenced by increased brain LDH activity and reduced brain MDA level. Treatment of STZ-treated rat with BECS was also able to significantly (p<0.01) regulate markers of brain dysfunction (AChE and BChE activities and glutamate ,dopamine levels). Additionally, treatment of rats with BECS efficacy restored the GSH level and GSH-system enzymes towards normal levels. Regarding the levels of (IL-6, TNF-α, and NO) produced by diabetogenic effects of STZ, the BECS successfully regulated these inflammatory mediators. From all these results, the neuroprotective effect of BECS could be due to its richness in polyphenols identified by LC-MS/MS (both positive and negative modes) analysis, mainly chlorogenic acid and rutin, as well as the synergistic interactions of all contents.

DOI

10.21608/ejchem.2022.156714.6790

Keywords

Diabetic neuropathy, Sreptozotocin, Capparis spinosa, LC-MS/MS analysis, Oxidative Stress, Inflammation

Authors

First Name

Ibtissem

Last Name

Sakrani

MiddleName

-

Affiliation

Laboratoire de Biologie et Environnement, Facult&eacute; des Sciences de la Nature et de la Vie, Universit&eacute; des Fr&egrave;res Mentouri Constantine1, Alg&eacute;rie

Email

besma.ibt@hotmail.com

City

Constantine

Orcid

-

First Name

Souad

Last Name

Ameddah

MiddleName

-

Affiliation

Laboratory of Biology and Environment, Faculty of Nature and Life Sciences,University Mentouri Brothers

Email

amedsouad@yahoo.fr

City

Constantine

Orcid

https://orcid.org/00

First Name

Mouad

Last Name

Benrebaia

MiddleName

-

Affiliation

aLaboratoire de Biologie et Environnement, Facult&eacute; des Sciences de la Nature et de la Vie, Universit&eacute; des Fr&egrave;res Mentouri Constantine1, Alg&eacute;rie

Email

mouad@umc.edu.dz

City

Constantine

Orcid

-

First Name

Abdelahami

Last Name

Bouaroudge

MiddleName

-

Affiliation

Laboratoire des produits naturels d&#039;origine v&eacute;g&eacute;tale et de synth&egrave;se organique Universit&eacute; des Fr&egrave;res Mentouri Constantine, Alg&eacute;rie

Email

bouarroudjhamid@gmail.com

City

Constantine

Orcid

-

First Name

Ramazan

Last Name

Erenler

MiddleName

-

Affiliation

cDepartment of Chemistry, Faculty of Arts and Sciences, TokatGaziosmanpaşa University, 60240, Tokat, Turkey

Email

ramazan.erenler@gop.edu.tr

City

Tokat

Orcid

-

First Name

Rachid

Last Name

Benkiniouar

MiddleName

-

Affiliation

Laboratoire des produits naturels d&#039;origine v&eacute;g&eacute;tale et de synth&egrave;se organique Universit&eacute; des Fr&egrave;res Mentouri Constantine, Alg&eacute;rie

Email

benkiniouar@msn.co

City

Constantine

Orcid

-

First Name

Ercan

Last Name

Cacan

MiddleName

-

Affiliation

Department of Molecular Biology and Genetics, Gaziosmanpasa University, 60250 Tokat, Turkey

Email

ercancacan@gmail.com

City

Tokat

Orcid

-

First Name

Ahmed

Last Name

menad

MiddleName

-

Affiliation

Laboratoire de Biologie et Environnement, Facult&eacute; des Sciences de la Nature et de la Vie, Universit&eacute; des Fr&egrave;res Mentouri Constantine1, Alg&eacute;rie

Email

menadahmed@yahoo.fr

City

Constantine

Orcid

https://orcid.org/00

Volume

65

Article Issue

132

Related Issue

39238

Issue Date

2022-12-01

Receive Date

2022-08-16

Publish Date

2022-12-01

Page Start

519

Page End

538

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 132_Pages 519-538.pdf

PDF . 1.5MB

Link

https://ejchem.journals.ekb.eg/article_266377.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=266377

Order

266,377

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Algerian Capparis spinosa n-BuOH Extract Alleviates Diabetic Neuropathy Induced with Streptozotocin in Rats

Details

Type

Article

Created At

30 Dec 2024