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244907

Newly Created Hybrid Nanomaterial for Treatment of Lung Carcinoma

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Nano chemistry

Abstract

Deficient passage of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Interest has been manifested in use of chitosan-based nanoparticles with utilizing metal oxide hybrid nanocomposite in nanomedicine. We synthesis, characterize, and investigate a hybrid nanomaterial (CHNM) anti-cancer activity. A developed CHNM of magnesium oxide nanoparticles coupled with cisplatin and coated with chitosan biopolymer were characterized by FTIR, X-ray diffraction, TEM and SEM. Anti-cancer effects were evaluated in A549 cell line. CHNM nanoparticles showed a diameter of ∼240 nm with a negatively charged surface (−25.4 ± 3.75 mV) and mean particle size of 24.2 ± 7.89 nm. CHNM showed a high encapsulation efficiency (78%), drug loading efficiency (80%) and maximum cisplatin release (2- 6 h). CHNM showed improved anti-cancer activity on A549 cells (IC50=50.8 µg/ml). In conclusion, magnesium oxide nanoparticles coupled with cisplatin and coated with chitosan biopolymer could be used as promising lung cancer treatment system.

DOI

10.21608/ejchem.2022.134874.6127

Keywords

Lung Cancer, Cisplatin, hybrid nanomaterial, Chemotherapy

Authors

First Name

Aya

Last Name

Shaaban

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of science, Ain Shams University, Cairo, Egypt

Email

aya.shaaban@sci.asu.edu.eg

City

-

Orcid

-

First Name

Ahmad

Last Name

Salem

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of science, Ain Shams University, Cairo, Egypt

Email

ahmed.salem@sci.asu.edu.eg

City

-

Orcid

-

First Name

Faten

Last Name

Elramly

MiddleName

-

Affiliation

Faculty of science and humanities Prince Sattem Bin Abd Alaziz University, Hawtit Ban Tamim; Saudia Arabia

Email

fatenelramly555@yahoo.com

City

-

Orcid

-

First Name

Ekrami

Last Name

ahmed

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of science, Ain Shams University, Cairo, Egypt

Email

ekrami.ahmed@sci.asu.edu.eg

City

Cairo

Orcid

0009-0001-9477-6795

First Name

fatma

Last Name

Moawed

MiddleName

-

Affiliation

Health radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

Email

fatmasearch5@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Hegazy

MiddleName

Galal Eldeen

Affiliation

Biochemistry, faculty of Science, Ain Shams university

Email

marwa_hegazy2000@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

131

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-05-20

Publish Date

2022-12-01

Page Start

1,543

Page End

1,550

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 131_Pages 1543-1550.pdf

PDF . 537.8kB

Link

https://ejchem.journals.ekb.eg/article_244907.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=244907

Order

244,907

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Newly Created Hybrid Nanomaterial for Treatment of Lung Carcinoma

Details

Type

Article

Created At

30 Dec 2024