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243066

Efficient Organocatalytic Chiral Synthesis of (R)-Pipecolic Acid

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Aldehyde obtained from unsymmetrical cleavage of cyclohexene by ozonolysis is subjected to L-proline catalyzed asymmetric α-amination reaction to obtain chiral amino alcohol with >99% ee which is subsequently converted into (R)-6-(hydroxymethyl)piperidin-2-one and (R)-pipecolic acid. Overall, a short and efficient asymmetric synthesis of (R)-pipecolic acid is described employing organocatalytic asymmetric α-amination of aldehyde as key step.

DOI

10.21608/ejchem.2022.126431.5609

Keywords

organocatalysis, α -amination of aldehyde, pipecolic acid, unsymmetrical ozonolysis

Authors

First Name

Sharad

Last Name

Panchgalle

MiddleName

Pandit

Affiliation

Department of Chemistry, K. M. C. College Khopoli, Taluka Khalapur, Dist. Raigad, Maharashtra, India

Email

panchgalle@gmail.com

City

Khopoli

Orcid

0000-0001-9706-7567

First Name

Vijaykumar

Last Name

More

MiddleName

S.

Affiliation

Department of Chemistry, Kai Rasika Mahavidyalay Deoni, Dist. Latur 410203, India

Email

vijaymore@gmail.com

City

Deoni

Orcid

-

First Name

Mahesh

Last Name

Khanvilakr

MiddleName

B.

Affiliation

Department of Chemistry, K. M. C. College Khopoli, Taluka Khalapur, Dist. Raigad, Maharashtra, India

Email

mb.khanvilkar@gmail.com

City

Khopoli

Orcid

-

Volume

65

Article Issue

131

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-03-10

Publish Date

2022-12-01

Page Start

1,441

Page End

1,446

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 131_Pages 1441-1446.pdf

PDF . 303.9kB

Link

https://ejchem.journals.ekb.eg/article_243066.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=243066

Order

243,066

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Efficient Organocatalytic Chiral Synthesis of (R)-Pipecolic Acid

Details

Type

Article

Created At

30 Dec 2024