Background: Every year, there are more and more cases of cervical cancer worldwide. Users of intrauterine devices (IUDs) have also grown because they believe IUDs to be more secure. The current study aimed to assess the association between the long-term use of Intrauterine Contraceptive Device (IUCD) and the development of cervical intra-epithelial neoplasia through cytologic and colposcopic examination of patients using IUCDs for a long period of time and to create awareness among the IUCD users for regular follow up. Patients and methods: Cross sectional observational study conducted in outpatient clinic and Endoscopic unit of Obstetrics and Gynecology Department and Department of Pathology at Zagazig University Hospitals. Eighty-five females who used IUCD at least 2 years were included. Age of our studied females ranged from 21 to 45 years with mean 34.24±7.14 years. All women were subjected to complete history-taking, cervical smear examination and a colposcopic was collected. Results: Among 85 copper T IUD users, abnormal PAP smear findings were reported in 89.4% of females. Among the 6 (7%) females who underwent colposcopy, 3 (3.5%) females were normal and 3 (3.5%) females had abnormal findings. There was no reported cases of high grade squamous intra-epithelial lesion or squamous carcinoma. Moreover, pathological examination revealed low grade squamous intra-epithelial lesion in all females with abnormal colposcopy findings (3.5%). Conclusion: we concluded that the use of IUD as a contraceptive method decreases the risk of the development of cervical cancer.