Background: Comedones, papules, nodules, and scars are the hallmarks of acne vulgaris. In patients who are prone to scarring, scarring is a common consequence. There appears to be an improvement in skin texture and structural volumization with injections of Nanofat mixed with microfat. Platelet Rich Plasma use in regenerating damaged tissues has attained a lot of interest. Glutathione has remarkable antioxidant properties, skin lightening effect and has also been found to decrease wrinkles and increase skin elasticity. Glutathione is used as monotherapy or in combination with PRP. This study aimed to investigate Nanofat in the treatment of post-acne scar in comparison with platelet rich plasma added to glutathione injection.

Subjects and methods: This comparative clinical study included 24 patients complaining of post-acne scars; selected from Plastic Surgery Department, Zagazig University Hospitals. Nano-fat injection treatment was applied on the right side of the face and the PRP with glutathione injection was applied on the left side of the face.

Results: Statistically significant differences were found between Pre and Post Goodman-Baron acne scar grading among Nano-fat injection group and among PRP+ glutathione group (p=0.006,0.009 respectively). Post-inflammatory hyperpigmentation was significantly higher among Nanofat group (45.8%) in comparison to (12.5%) among PRP+ glutathione group (p=0.01).

Conclusion: IInjection of Nanofat could be an effective scar treatment leading to statistically significant improvements in scar appearance, PRP injection in combination with glutathione is also an effective treatment in improvement of post acne scars appearance. These therapeutic procedures provide a valuable tool for every plastic surgeon.