Background: The most frequent benign tumor in females is uterine myoma, which is derived from the myometrium of the uterus. Multiple studies have reported rates of occurrence varying between twenty percent to forty percent. The histological diagnosis indicates a significantly higher frequency compared to the clinical diagnosis. Therefore, the treatment of the hemorrhage is contingent upon the estimation of the hemorrhage and the alterations that happen during the operation. Aim of the Work: To compare the effectiveness of placebo and tranexamic acid during transabdominal myomectomy for reducing the bleeding. Patients and Methods: Blinded randomized controlled research, while 50 females with uterine fibroids were divided and equally classified among two groups, each group contained 25 females. Prior to the abdominal myomectomy, each woman received a slowly intravenous injection of tranexamic acid fifteen milligrams per kilogram or placebo over a period of between five and ten minutes. The amount of blood loss was assessed. Results: The tranexamic acid group showed low blood loss, participants needing blood transfer, or additional intervention, in comparison to the placebo group. Furthermore, the participants that received tranexamic acid injections showed higher hemoglobin and hematocrit levels than those that received placebo injections following surgery. Conclusions: The parameters that were assessed together with the adverse and beneficial consequences of the study drugs, showed as follows: The hematologic profile and hemodynamics may be established, which might result in tranexamic acid being more efficient compared to a placebo in reducing the need for blood transfusions.