Abstract: Clusterin serves as a highly sensitive cellular detector for oxidative stress ‎and has been extensively investigated as a significant indicator for disorders related ‎with inflammation. The evaluation of clusterin in pediatric population diagnosed ‎with has not been fully evaluated. Methods: This is a case-control study. It was a ‎prospective study carried on Pulmonology unit Pediatric department, Zagazig ‎University hospitals including 54 Patients 7 – 14 years in age, both genders were ‎included, this study was planned to include fifty four (54) subjects; thirty six (36) ‎asthmatic children as patients and another eighteen (18) healthy children as controls. ‎Results: In the current research we had reported that there was astatistically ‎significant disparities between studied groups regarding sputum clusterin (p value of ‎‎≤0.001) as children diagnosed with stable asthma had elevated levels of clusterin ‎compared to the healthy control group [14.82(13.74–16.59) ng/mL vs 11.75 (10.82-‎‎12.54) ng/mL]. During asthma exacerbation, the levels of clusterin in sputum were ‎decreased compared to stable asthma [8.13 (4.31–9.41) ng/mL vs 14.82 (13.74–‎‎16.59) ng/mL]. Our investigation reported a statistically significant association ‎between the severity of asthma and serum Clusterin in severe asthma as patients with ‎severe asthma had elevated levels of clusterin in comparison to those who had mild ‎asthma [16.47 (15.76–18.12) ng/mL vs 13.79 (12.85-14.03) ng/mL]. Conclusion: Clusterin levels detected in sputum can be considered as a biomarker of ‎airways inflammation and the intensity of symptoms, making it a valuable tool for ‎evaluating and treating childhood asthma.‎