Background: Helicobacter pylori is one of the most prevalent infections in humans, it can cause gastrointestinal (GI) problems such as simple gastritis, gastric ulcers, and gastric cancer. It may pose an issue as opportunistic infections in specific situations, such as immunodeficiency and underlying illnesses. One of the underlying disorders caused by H. pylori is diabetes mellitus. Treating the H. pylori infection is essential since diabetic people have GI issues. There are conflicting and erratic reports on Helicobacter pylori infection in diabetics. This study is the first at Zagazig University, as far as I know.

Aim: To reveal the severity of H. pylori among diabetic and non- diabetic patients and to identify the potential risk factors of H. pylori among diabetic.

Subjects and methods: This case control study was carried out at Internal Medicine Department and Pathology Department, Faculty of Medicine, Zagazig University. Subjects were divided into group (1): 27 patients with DM and group (2): 27Non-diabetic individual's age and sex matched as control.

Results: The severity of H. pylori gastritis was insignificantly different between the studied groups.

Conclusion: Our results do not support an association between severity of H. pylori infection and diabetes mellitus. This is confirmed by the lack of difference between diabetics and nondiabetics regarding the severity of H. pylori infection.