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341855

Magnetic Resonance Imaging Evaluation of ‎Myocardial and Hepatic Iron Overload in Beta-‎Thalassaemia

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Radiodiagnosis

Abstract

‎Background: Beta-Thalassemia major is an inherited condition characterized by a kind of ‎anemia that causes the destruction of red blood cells, and a significant complication of this ‎condition is the accumulation of excessive iron in body. Magnetic resonance imaging is the ‎most commonly accessible modality that considered non-invasive for identifying or measuring ‎the extent of iron buildup, as well as tracking the effectiveness of treatments that reduce iron ‎levels. Methods: Prospective study involved 35 beta thalassemia thalassemia. 1.5 Tesla MRI machine was used to ‎perform MRI scans of the liver and heart in all subjects in order to evaluate iron in the heart muscles or liver. Results: Serum ferritin among studied ‎patients had a range from 300 up to 10000 ng /ml with a mean value of 3013.86 ± 3000.5 SD. ‎There was no significant correlation between age or sex and hepatic or cardiac magnetic ‎resonance imaging findings, but there was a significant negative correlation between ‎ferritin levels with hepatic MRI T2 (P =0.037). Also, it was reported a statistical significant ‎positive correlation between ferritin levels and R2 and LIC. It was noticed no significant ‎correlation between ferritin levels assessed in the serum and cardiac MRI findings (P >0.05). ‎As the grade of hepatic iron overload increase, ferritin levels increases. Conclusion: T2* MRI is currently the ‎ perfered tool for early detection, measurement, and monitoring of iron overload in the ‎liver and heart. It is used to guide chelation therapy, which helps prevent iron-related heart ‎problems and minimize patient mortality.‎

DOI

10.21608/zumj.2024.263788.3123

Keywords

Keywords: MRI, Beta-Thalassamia, ferritin, iron

Authors

First Name

Heba

Last Name

Tantawy

MiddleName

F.

Affiliation

radiology department, Faculty of medicine

Email

hebatantawy1980@gmail.com

City

-

Orcid

0000-0001-5932-303X

First Name

Esraa

Last Name

Abdallah

MiddleName

-

Affiliation

Radiology Department, Zagazig University, Egypt

Email

esraaabdalla191@gmail.com

City

-

Orcid

-

First Name

Khalid

Last Name

Shawky

MiddleName

-

Affiliation

Radiology Department, Zagazig University, Egypt

Email

kshawkyfawzi@hotmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Abd Elhamed

MiddleName

Elsayed

Affiliation

Radiodiagnosis, faculty of Medicine, Zagazig University, Zagazig

Email

dr.meroelsayed34@gmail.com

City

Zagazig

Orcid

0000-0001-6777-579x

Volume

30

Article Issue

8

Related Issue

51284

Issue Date

2024-11-01

Receive Date

2024-01-19

Publish Date

2024-11-01

Page Start

4,564

Page End

4,578

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_341855.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=341855

Order

28

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Magnetic Resonance Imaging Evaluation of ‎Myocardial and Hepatic Iron Overload in Beta-‎Thalassaemia

Details

Type

Article

Created At

30 Dec 2024