Abstract

Background: Breast cancer is regarded as the second leading cause of cancer-related mortality among women and the most widespread malignancy affecting females globally. Our research seeks to elucidate the function of sorcin and annexin A3 in the detection of breast cancer.

Methods: This research involved 59 female cases selected from the South Egypt Cancer Institute, Surgery Department, and Assiut University for the period March 2019 to December 2019. They were separated into two groups as follows: Prior to the procedure, Group one involved 48 women with breast cancer, and Group two involved 11 women with benign breast diseases. The control group consisted of 15 female volunteers recruited from staff or colleagues and screened with a thorough history and examination.

Result: The breast cancer group had significantly higher levels of sorcin relative gene expression and annexin A3 compared to the control and benign groups (p-value < 0.001 for each). Additionally, the benign group showed a statistically significant difference in sorcin relative gene expression compared to the controls.

Conclusion: In terms of our findings, we concluded that Sorcin gene expression represented significantly higher diagnostic accuracy for breast cancer yielding AUC 0.933 with 93.75% sensitivity and 84.62% specificity compared to ANXA3 level, which represented significant diagnostic accuracy for breast cancer yielding AUC 0.779 with 83.33% sensitivity and 65.33% specificity.