Abstract
Background: Cardio vascular diseases prevalence increases in developing countries. Gated single-photon emission computed tomography (SPECT) has taking-over the myocardial perfusion imaging (MPI) studies. It is also known that in symptomatic patients, SPECT MPI has high diagnostic accuracy for the detection of significant cardio-vascular diseases (CVD).

Aim of the work: to build up a normal local reference for left ventricular functional parameters (ejection fraction, end diastolic volume and end systolic volume) in rest and post stress conditions by gated SPECT myocardial perfusion scan and to compare it with global references of different populations that may help the process of prevention, early intervention, and dispensing unnecessary invasive interventions based on gated SPECT MPI results.


Subjects and methods: This was Cross sectional observational study. We retrospectively analyzed 80 patients sent for rest/stress gated SPECT with Tc-99 MIBI because of suspected coronary artery disease (CAD).
Results: EF at rest was significantly higher than stress in our studied group, There was no significant difference between our study finding and international value, international European value as regard EF, but regard ESV and EDV they were significantly higher among international value. Significant gender differences between parameters were recorded.

Conclusion: evaluation of cardiac function and volumes by gated SPECT should consider gender-matched normative values and to much extent influenced by ethnicity or geographical origin with normalization of other variables such as isotope used and number of frames per cycle should also be considered when interpreting results, since accuracy of measurements can be affected.