Objectives: The goal of this study is to evaluate the effect of biofilms on the outcome of the functional endoscopic sinus surgery for the patients with chronic rhinosinusitis.
Methods: The study design involved a retrospective analysis of prospectively collected data in a tertiary hospital. The subject population consisted of 25 consecutive patients undergoing ESS for CRS. The diagnosis of CRS was made according to the criteria set out by the Rhinosinusitis Task Force and endorsed by the American Academy of Otolaryngology. Patients included in the study has received standardized preoperative medical therapy.
Results: We studied 25 patients with mean age of 34.68±11.44, regard sex distribution the majority were male. Age was distributed as 34.68±11.44 with minimum 18 and maximum 11.44 years, regard sex distribution male were 64.0% and female 36.0%, and 32.0% of studied group were smoker. 72.0% of studied group had co-morbidity the majority were allergic 48.0% and only 32.0% had previous surgery. 72.0% of studied group had nasal block and it was the most prevalent symptom, headache in 56.0%, post nasal drip 36.0%, hyposmia in 48.0%, polyp in 36.0% and facial pain in 56.0%
Conclusion: Biofilm positive -patients tend to have a greater severity of the disease preoperatively and continue to have persistent and more severe symptoms post-ESS, with ongoing mucosal inflammation and recurrent infections. This study strengthens the evidence for the role that biofilms may play in recalcitrant CRS. Therapies targeted at removing biofilms may be important in the management of recalcitrant CRS.