Background: Wound care begins with acute phase and continues through enhancement of scar tissue remodeling. In order to facilitate healing, physician aims at enhancing wound care. Numerous clinical study investigators have documented advantages of Low-level Laser Therapy (LLLT) on tissue healing which was described as a regenerative treatment to enhance wound healing at site of a skin graft donor site. The present work aimed to achieve patient satisfaction and aesthetic outcome of the donor site regarding wound healing.

Methods: This clinical trial study was conducted on 23 cases with raw area for split-thickness skin graft (STSG) within the period from December 2022 to November 2023. All participants were subjected to complete history taking, including personal, complaint, present, past, and family history. Patient Communication and explanation of the procedure and postoperative management. Full clinical examination, either general for all systems or local wound examination.

Results: Regarding 5th-day BWAT score items, there was no remarkable variance between the two groups (P >0.05). There was substantial variance between the groups concerning size and depth (p<0.05). There was substantial variation between the studied groups concerning 10th-day BWAT score items (Peripheral tissue edema, granulation tissue, and total score) (P<0.05).

Conclusion: On 10th day, Laser group displayed better wound size and depth outcomes, along with favorable results in exudate quantity and type, skin color around wound, peripheral tissue edema, granulation tissue, and overall wound assessment score compared to Control group. These findings collectively suggest that laser therapy contributes to improved wound healing and scar management outcomes.