Background: The main objective of this study is to assess and compare the diagnostic accuracy ‎of pipelle biopsy and D&C hysteroscopic guided biopsy with the usual pathology following ‎surgical hysterectomy. Methods: This research was conducted as a prospective cross-sectional ‎analysis and involved seventy two participants who were divided into 3 groups. Group A ‎offered formal dilatation and curettage (n=24), Group B offered pipelle cytology (n=24), Group ‎C offered hysteroscopic directed biopsy (n=24). Results: ROC-curve analysis was employed to ‎assess the performance of the formal D&C biopsy approach in identifying patients with ‎malignancy. The method demonstrated good accuracy, with a sensitivity of 63% and specificity ‎of 100% (p < 0.01). The hysteroscopic guided biopsy approach accurately identified individuals ‎with cancer, demonstrating exceptional accuracy, with a sensitivity of 91% and specificity of ‎‎100% (p < 0.01). The Pipelle approach accurately recognized individuals with cancer, ‎exhibiting exceptional accuracy, with a sensitivity of 90% and specificity of 100% (p < 0.01). ‎Conclusion: Pipelle endometrial sample and hysteroscopy are simple and secure techniques for ‎obtaining tissue diagnosis.‎