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360972

Brief Overview about Inherited Rare coagulation disorders

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pediatrics

Abstract

Background: Numerous rare congenital bleeding disorders include fibrinogen and prothrombin deficiency as well as factor (V, VII, VIII, XI, X, and XIII) deficiency. In the general population, the severe variants of these illnesses are hereditary and possess a frequency that falls somewhere between one in every two million for factor XIII and one in per half a million for factor VII. Patients who have rare congenital bleeding disorders may exhibit a broad range of symptoms, from relatively mild subcutaneous bleeding to potentially life-threatening hemorrhages for example in the central nervous system. The majority of treatment for these disorders when specific plasma-derived or recombinant products are available is to replace the missing factor. Diagnosing and treating rare congenital bleeding disorders can be challenging due to the wide variety of symptoms they manifest in patients. Patients with rare inherited bleeding diseases must be closely monitored at specialized hemophilia treatment centers once they are diagnosed, due to the unique difficulty of their therapy. More research is required to improve the worldwide care for individuals with rare inherited bleeding diseases, despite the fact that a lot has been learned about their frequency, symptoms, and genetic characteristics in the past ten years. We aimed at this review to give a brief overview about Inherited Bleeding Disorders.

DOI

10.21608/zumj.2024.297107.3440

Keywords

Inherited Bleeding Disorders, rare, coagulation disorders

Authors

First Name

Laila

Last Name

Sherief

MiddleName

M

Affiliation

Pediatrics Department, Faculty of Medicine, Zagazig University

Email

lamesh250@gmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Zakaria

MiddleName

-

Affiliation

pediatric department, faculity of medicine, zagazig university

Email

marwazakaria12@yahoo.com

City

zagazig

Orcid

0000-0003-3562-7789

First Name

Ahmed

Last Name

Abd El Fattah

MiddleName

Ali

Affiliation

Pediatrics Department, Faculty of Medicine, Zagazig University

Email

ahmedelkomy700@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Hamed

MiddleName

S.

Affiliation

Public Health and Community Medicine Department, Faculty of Medicine, Zagazig University

Email

drmonasami@yahoo.com

City

-

Orcid

-

Volume

30

Article Issue

7

Related Issue

50602

Issue Date

2024-10-01

Receive Date

2024-06-11

Publish Date

2024-10-01

Page Start

3,414

Page End

3,422

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_360972.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=360972

Order

22

Type

Review Articles

Type Code

349

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Brief Overview about Inherited Rare coagulation disorders

Details

Type

Article

Created At

30 Dec 2024