One trustworthy substitute biomarker of insulin resistance (IR) has been found to be the triglyceride glucose (TyG) index. The development and prognosis of cardiovascular disease (CVD) have been linked to the triglyceride glucose index, according to a significant number of recent research that have produced strong statistical support for this theory. However, there is even less data available about the underlying mechanisms linked to cardiovascular illness, and the use of the triglyceride-glucose index as a marker of cardiovascular disease has not been thoroughly examined. In light of this, we provide a brief overview of the development of the triglyceride-glucose index as a stand-in marker for insulin resistance in this review. In order to increase the triglyceride glucose index's usefulness for cardiovascular disease and offer more thorough and accurate supporting data, we set out to demonstrate the index's application value for a range of cardiovascular disease types and investigate any potential drawbacks associated with its use as a predictor of cardiovascular events. Conclusion: The results suggest that while fasting and postprandial triglyceride glucose indices may not be independent predictors of CAD severity in non diabetic patients, The TyG index was not independently relevant to adverse cardiovascular events in nondiabetic patients who underwent PCI. However, in subjects with LDL-C lower than 70 mg/dl , it may predict adverse cardiovascular prognosis.