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291882

Epicardial Adipose Tissue as a New Biomarker for Insulin Resistance and Predictive of Prediabetes

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Internal Medicine

Abstract

Background: Type 2 diabetes is predisposed by increased visceral obesity, insulin resistance, and B-cell dysfunction. Obesity, diabetes mellitus, and the metabolic syndrome are all risk factors for increased epicardial adipose tissue (EAT) thickness. Few published studies have examined the significance of EAT thickness in prediabetic patients and how it relates to insulin resistance, HbA1c levels, and the length of diabetes. Aim: The goal was to look at the relationship between EAT and the likelihood of developing Type 2 DM. Subjects and methods: This study included 69 subjects. Subjects were split into the following three groups: Group I consists of 23 individuals who have good blood sugar levels, Group II consists of 23 patients with prediabetes, and Group III consists of 23 patients with type 2 diabetes. All patients underwent transthoracic echocardiography to estimate epicardial adipose tissue thickness. Results: Our study reveals a statistically significant difference between the tested groups in terms of their thicker epicardial adipose tissue in diabetes than prediabetes group(p<0.05). The median epicardial fat thickness (EFT) was considerably greater in the group of people with prediabetes than healthy control group (p<0.05). There is significant and direct relation between EAT thickness of studied groups as well as HOMA-IR, BMI, and waist size (p<0.05). Conclusion: The EAT is simple, inexpensive, readily available, non-invasive, and a predictor of development of prediabetes and Type 2DM.

DOI

10.21608/zumj.2023.199083.2765

Keywords

Epicardial adipose tissue, Insulin Resistance, Prediabetes, Type 2 diabetes mellitus

Authors

First Name

Fatma

Last Name

Amer Leaimesh

MiddleName

Said

Affiliation

2Department of Internal Medicine and Endocrinology, Faculty of Medicine, Sirt University, Libya

Email

sirt0949@gmail.com

City

-

Orcid

-

First Name

Ayman

Last Name

Nsr-Allah

MiddleName

A.M.

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine, Zagazig University, Egypt

Email

ayman_abd1971@yahoo.com

City

-

Orcid

-

First Name

Islam

Last Name

Shehata

MiddleName

Elsayed

Affiliation

ZAssistant Professor of Cardiology, Department of Cardiology, Faculty of Medicine, Zagazig University, Zagazigagazig University Faculty of Human Medicine

Email

iemshehata@zu.edu.eg

City

Zagazig

Orcid

0000-0002-3850-9027

First Name

Azza

Last Name

Abd-El Fatah

MiddleName

H.

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine, Zagazig University, Egypt

Email

azza.hassan4578@gmail.com

City

-

Orcid

-

Volume

30

Article Issue

1.6

Related Issue

50336

Issue Date

2024-09-01

Receive Date

2023-03-09

Publish Date

2024-09-01

Page Start

2,818

Page End

2,831

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_291882.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=291882

Order

15

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Epicardial Adipose Tissue as a New Biomarker for Insulin Resistance and Predictive of Prediabetes

Details

Type

Article

Created At

30 Dec 2024