COVID-19 belongs to Coronaviruses family, which were first identified in humans in 1965 from a child with an upper respiratory infection.in contrast with infected adults, most infected children appear to have a milder clinical course and asymptomatic infections were not uncommon. No neurological complications were reported children at the start of the pandemic. Neurological complications of COVID-19 appear to be both infrequent and diverse in nature. Virtually any part of the neuroaxis appears to be susceptible to injury with SARS-CoV2. Neurological disease may be the consequence of generalized cardiorespiratory failure and metabolic abnormalities triggered by the infection, direct invasion of the virus, or an autoimmune response to the virus. My observation will be two cases report which could trigger researchers to ask many questions regarding pathogenic mechanisms that underlie the occurrence of neurologic injury in our young patients. In other words, is it related to specific host factors in those children that increase their susceptibility to be involved or related to a newly acquired antigenic virulence that enhance SARS-CoV-2 to have more predilections to Nervous system.