Background: A number of advancements have been implemented in recent years to reduce pain during office hysteroscopy and boost completion rates, for reduction of this pain, many drugs are offered as Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol. Paracetamol act centrally by inhibition of brain cyclooxgynase (Cox). This study aimed to assess the analgesic effect of paracetamol and ipubrofen tablets in pain perception during and after outpatient diagnostic hysteroscopy without anaesthesia. Patients and methods: This was a Prospective, Randomized- Controlled clinical trial, conducted at the endoscopy unit of obstetrics and gynecology department at Zagazig university hospitals. Sixty patients included in our trial. The included women were divided into 3 groups; control group: did not receive any medication before the procedure. Group 2 (Paracetamol group): included 20 women received a 1000-mg oral paracetamol tablet, Group 3 (Ibuprofen group): included 20 women received a ibuprofen 600-mg tablet of the same appearance. The treatment was given one hour before the hysteroscopy. Results: The main indication for hysteroscopy was abnormal uterine bleeding in paracetamol group 12(60%), ibuprofen group 10(50%) and control group 7(35%). We found that uterine polyps were the major findings. In paracetamol group 8(40%), ibuprofen group 8(40%) and control group 5(25%). The pain scores, which comprised the VAS before hysteroscopy (p=0.976) and the VAS following hysteroscopy (p=0.832). Conclusion: The injection of ibuprofen and paracetamol one hour before to an office hysterscopy did not lessen pain during the procedure.