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357975

Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pathology

Abstract

Abstract

Background: Bladder carcinoma is the second most common cause of death among all genitourinary tumors. Tumor recurrence, multifocality and metastasis are main causes of related mortality The primary objective of the present study is to evaluate the expression of Sp1 and Par3 in urinary bladder carcinoma and to investigate their correlation with clinicopathological characteristics and patient survival

Patients and Methods: This prospective cohort study included 50 urothelial carcinoma cases investigated for immunohistochemical expressions of Sp1 and Par3 followed them for five years or until death. The expression of markers in all tissue samples was assessed, analyzed, and correlated with clinical-pathological parameters and outcomes.

Results: The high expression of Sp1, and low expression of Par3 was significantly associated with poor clinicopathological characteristics and unfavourable overall survival.

Conclusion: The results suggested that Sp1 and Par3 may have roles in modulation of tumor invasion. Sp1 and Par3 may serve as valuable prognostic markers or therapeutic targets for urothelial carcinoma.

DOI

10.21608/zumj.2024.284107.3347

Keywords

Prognosis urothelial carcinoma, mortality, metastasis

Authors

First Name

Enass

Last Name

Fouad

MiddleName

Mohammed

Affiliation

Pathology department, zagazig univeristy, faculty of medicine,Zagazig. Egypt

Email

enasssmohammed2022@gmail.com

City

-

Orcid

-

First Name

Shimaa

Last Name

Gharieb

MiddleName

Abd allah

Affiliation

Clinical oncology zagazig university , faculty of medicine,Zagazig. Egypt

Email

shimaagharieb222@gmail.com

City

-

Orcid

0000-0003-0775-1272

First Name

Amira

Last Name

Hanna

MiddleName

Hany

Affiliation

Clinical oncology, Zagazig university, faculty of medicine,Zagazig. Egypt

Email

amirahanna999@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdelaleem

MiddleName

-

Affiliation

urology department, zagazig univeristy, faculty of medicine, Zagazig. Egypt

Email

drmoaleem@gmail.com

City

-

Orcid

-

First Name

Eslam

Last Name

abozaid

MiddleName

-

Affiliation

Department of general surgery faculty of medicine Zagzig university

Email

eslamabozaidsurgery@gmail.com

City

-

Orcid

-

First Name

asmaa

Last Name

Abdullatif

MiddleName

-

Affiliation

pathology department. Zagazig university. faculty of medicine,Zagazig . Egypt

Email

asma_abdullateef@hotmail.com

City

zagazig

Orcid

-

First Name

Enass

Last Name

Fouad

MiddleName

Mohammed

Affiliation

pathology,faculty of medicine,Zagazig univeristy,Egypt

Email

drenasss2020@gmail.com

City

-

Orcid

-

Volume

30

Article Issue

6

Related Issue

50059

Issue Date

2024-09-01

Receive Date

2024-05-04

Publish Date

2024-09-01

Page Start

2,334

Page End

2,344

Print ISSN

1110-1431

Online ISSN

2357-0717

Article File

ZUMJ_Volume 30_Issue 6_Pages 2334-2344.pdf

PDF . 971.9kB

Link

https://zumj.journals.ekb.eg/article_357975.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=357975

Order

357,975

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma

Details

Type

Article

Created At

30 Dec 2024