Background: The prevalence of Metabolic syndrome in childhood has been raised in the last few years with serious medical and public health problem. However, very few previous studies have described its status in Egyptian children and adolescents. This study aimed at assessment of the prevalence and risk factors of Metabolic syndrome among children and adolescents in Benha city. Methods: This cross-sectional study included 910 participants from Benha city aged from 6 to 18 years. Anthropometric measurements: height, weight, BMI and WC and blood tests were conducted to assess components of metabolic syndrome defined according to the International Diabetes Federation criteria. Suitable statistical tests were adopted to define possible associations between Metabolic syndrome and other factors. Results: the mean age was 11.6 ± 3.4 years, 53% of subjects were males. 60% of subjects came from urban regions. The prevalence of metabolic syndrome was 5% (49 out of 910 subjects). There was insignificant difference in MetS prevalence between males and females p= 0.55. Low HDL-C (24%) and central obesity (17.7%) were the most prevalent components. while 10% had high BP, 10% had high TG and 9% had elevated FG. Females had higher frequency of central obesity than males (57%) vs. (43%), while males had significant higher frequency of Low HDL-C (65%) vs. (35%). Urban dwellers had higher rates of central obesity, high TG and elevated FG. Conclusion: The prevalence of metabolic syndrome (according to the definition of International Diabetes Federation) among children and adolescents living in Benha city, Egypt was 5%.