Beta
369112

Significance of plasma melatonin as a diagnostic marker in full-term with late onset sepsis

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pediatrics

Abstract

Background: When newborn sepsis occurs, the pathogen may trigger an uncontrollable systemic inflammatory response that results in oxidative damage. Melatonin released naturally, which acts as a safe antioxidant and free radical scavenger in newborns. Aim of the work was to evaluate the significance of plasma melatonin level in early diagnosis of late onset sepsis neonatal sepsis. Patients and Methods: 58 full-term babies were included in a case-control study at Zagazig University's neonatal intensive care unit. Twenty-nine newborns in the patient group had complete clinical and biochemical signs of sepsis. The control group included twenty-nine newborns with no clinical or biochemical signs of sepsis. Melatonin level was measured by ELISA, and a septic work-up was done for all the patients. Results: The best cutoff plasma melatonin level in the diagnosis of late onset sepsis was16.2 pg/ml with an area under the curve of 0.97, a sensitivity of 92.6%, specificity of 86.4%, positive predictive value of 90.5 %, negative predictive value of 87% and over all accuracy of 88.6%. Conclusion: A significant elevation of endogenous plasma melatonin level was found in late-onset neonatal sepsis, so early identification of late-onset sepsis could considerably help cases by allowing both the prevention of complications and avoiding multiple drug resistance.

DOI

10.21608/zumj.2024.294412.3425

Keywords

Key words: Neonatal sepsis, late-onset sepsis, Melatonin, and full-term

Authors

First Name

amani

Last Name

abdelaziz

MiddleName

-

Affiliation

-

Email

amaniahmed1973@yahoo.com

City

-

Orcid

-

First Name

Amal

Last Name

elshal

MiddleName

saeed

Affiliation

professor of biochemistry, faculty of medicine, zagazig university

Email

amalelshal@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdelbar

MiddleName

Tarek

Affiliation

internship ,faculty of medicine , zagazig university

Email

ahmedsalem7418@gmail.com

City

zagazig

Orcid

-

First Name

Marwa

Last Name

Mohammed Rashad

MiddleName

Lotfy

Affiliation

Pediatrics Department, Faculty of Medicine, Zagazig university

Email

drmarwalotfy414@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Mohammed Ali Elsharkawy

MiddleName

Mohammed

Affiliation

Pediatric Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Email

mona.elsharkawy86@yahoo.com

City

-

Orcid

-

Volume

30

Article Issue

5

Related Issue

49235

Issue Date

2024-08-01

Receive Date

2024-06-03

Publish Date

2024-08-01

Page Start

1,929

Page End

1,937

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_369112.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=369112

Order

369,112

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Significance of plasma melatonin as a diagnostic marker in full-term with late onset sepsis

Details

Type

Article

Created At

30 Dec 2024