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353665

Relation of XRCC1 Gene Polymorphism with Development of HCC among Patients with HCV Related Cirrhosis

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Clinical Pathology

Abstract

Background: Among Egyptian females, hepatocellular carcinoma (HCC) ranks sixth, while among males it ranks second. The X-ray repair cross-complementing group1 (XRCC1) could play a crucial role in reparation of oxidative DNA damage. An association was revealed between the risk of HCC and the genotypes and allele distribution of XRCC1 variants.

Objectives: This research aimed at the evaluation of the relationship between XRCC1 gene polymorphism and the development of HCC among Egyptian patients who had HCV related cirrhosis.

Patients and methods: This study recruited 93 individuals, including 31 apparently healthy subjects taken as controls (Group I), 31 cirrhotic patients with chronic hepatitis C virus (HCV) infection (Group II), and 31 HCC patients with HCV related cirrhosis (Group III). Xrcc1 gene polymorphism c.1517 G>C was determined using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism (PCR-RFLP).

Results: CC genotype was significantly increased (p=0.04) among HCC patients with HCV related cirrhosis (48.4%) compared to controls (12.9%). Also, C allele was significantly higher (p=0.01) among HCC patients (59.7%) compared to both cirrhotic patients (41.9%) and controls (33.9%). HCC patients had CC genotype 5.83 times more when compared to controls (OR=5.83, 95% CI= 1.46-23.3). HCC patients had C allele 2.89 times more when compared to controls (OR= 2.89, 95% CI= 1.39-6).

Conclusion: The polymorphism of XRCC1 c.1517G>C was found to be associated with increased risk of HCC among patients with HCV related cirrhosis, besides; C allele had higher risk of HCC.

DOI

10.21608/zumj.2024.285965.3362

Keywords

Hepatocellular carcinoma, xrcc1 polymorphism, Cirrhosis

Authors

First Name

Lamiaa.

Last Name

Kamel

MiddleName

M.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

lamneg@gmail.com

City

Zagazig

Orcid

-

First Name

Ola.

Last Name

Hussein

MiddleName

A.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

ola_aly1@hotmail.com

City

الزقازیق

Orcid

-

First Name

Rana.

Last Name

Ahmed

MiddleName

M.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

drranashalaby1991@gmail.com

City

-

Orcid

-

First Name

Amal.

Last Name

Jouda

MiddleName

A.

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt

Email

dr.amaljouda@yahoo.com

City

-

Orcid

-

First Name

Manal.

Last Name

El Gerby

MiddleName

M.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

manalelgerby@yahoo.com

City

-

Orcid

-

Volume

30

Article Issue

5

Related Issue

49235

Issue Date

2024-08-01

Receive Date

2024-04-28

Publish Date

2024-08-01

Page Start

1,633

Page End

1,640

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_353665.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=353665

Order

353,665

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Relation of XRCC1 Gene Polymorphism with Development of HCC among Patients with HCV Related Cirrhosis

Details

Type

Article

Created At

30 Dec 2024