Surgical revascularization is becoming more and more necessary for high-risk and elderly individuals with complicated coronary artery disease. After coronary artery bypass grafting (CABG), there is a substantial risk of both morbidity and death from cerebrovascular damage. The surgical approach used for CABG, and in particular the degree of aortic manipulation, has frequently been associated with the etiology of postoperative neurological problems, despite the possibility of several contributing factors. When revascularization (CABG) is necessary for coronary artery disease, the aortic clamping technique (SCT\DCT) is used. This approach affects the blood lactate level, which can lead to a number of postoperative problems. Elevated blood lactate level after cardiac surgery is an indicator of systemic hypoperfusion and tissue hypoxia. Our aim of the review was to evaluate the relationship between postoperative blood lactate levels and outcome in patients undergoing open heart surgery and to verify the clinical impact of hyperlactatemia (HL) and low lactemia (LL) after coronary artery bypass grafting (CABG) in terms of postoperative morbidity and mortality rate.