Abstract

Objective: We aimed to assess the correlation between atherogenic index of plasma (AIP) and spontaneous reperfusion (SR) in patients with ST elevation myocardial infarction (STEMI) and also to evaluate its relationship with in-hospital & mid-term outcomes.

Methods: The study included 259 STEMI patients. AIP was calculated from the lipid profile of all the STEMI patients, who underwent coronary angiography. SR was defined as achievement of grade 3 TIMI flow in the infarct-related artery (IRA) before PCI. We categorized patients into a SR group [57 (22%)] and a non-SR group [202 (78%)]. Gensini scoring system was used to evaluate the severity of CAD.

Results: The AIP value was higher in the Non-SR group than in the SR group [0.71 ± 0.11 vs. 0.56 ± 0.03; p <0 .001]. AIP had positive correlation (0.53, P<0.001) with severity of CAD. The in-hospital and mid-term adverse outcome was lower in patients with SR. AIP was found to be correlated with diabetes, hs-C-reactive protein, BNP, LA volume index and E/e'. Furthermore we observed that AIP was the strongest independent predictor for non-SR in STEMI patients. The cut-off value of AIP for predicting non-SR was ≥0.61, (AUC: 0.89).

Conclusion: Lower AIP is associated with the development of SR in STEMI patients. AIP was positively correlated well with the severity of CAD. High AIP is also associated with adverse outcomes. We found that higher AIP value was an independent predictor of non-SR. Hence, AIP could be advocated for routine measurement in clinical practice.