Background: Anemia is common complication in childern with chronic kidney disease (CKD) mainly anemia of chronic disease (ACD), but iron deficiency anemia (IDA) is also common. Soluble transferrin receptor (sTfR) is important marker for IDA, Objective: to evaluate the utility of soluble transferrin Receptor-Ferritin Indices as markers of IDA and for differentiation ACD from IDA in childern with chronic kidney disease , Patient and methods: cross-sectional study was conducted at Department of Pediatric Nephrology at Zagazig University Hospital including 45 anemic children (19 ACD, 13 IDA and 13 mixed). The duration of the study ranges from 6 to 12 months, Soluble serum transferrin receptor and Soluble serum transferrin receptor index were measured. Results: There was no significant difference among groups regard age or weight distribution. There was no significant difference regard sex distribution among studied groups. regard sTfR and sTfR index IDA group were significantly higher than other two groups then mixed and finally ACD were significantly lower. Conclusion: sTfR value was useful tool for assessment of iron status in patients with CKD, however, they are at best complementary to the existing indices of serum ferritin and TSAT.