Background: Type 2 diabetes mellitus (T2DM) is a multisystem chronic disease that has attained an epidemic scale. The microvasculature is harmed by persistent hyperglycemia, which eventually results in diabetic nephropathy, neuropathy, and retinopathy. Irisin was identified as a myokine that can affect several metabolic pathways.

Objectives: To investigate the value of irisin measurement in early detection of microvascular complications in adult T2DM patients.

Subjects and methods: This case-control study included 90 subjects divided into 3 equal groups: Group I of 30 healthy volunteers, group II of 30 adult T2DM patients without complications, and group III 30 adult T2DM patients with microvascular complications.

All studied subjects were subjected to clinical assessment and lab investigations that included routine parameters, cystatin C, urine albumin creatinine ratio as well as irisin measurement.

Results: Irisin was significantly lower in the patient groups. It showed moderate performance (AUC 0.674, p-value 0.007) with 70% sensitivity and 63.3% specificity for detection of microvascular complications.

Conclusion: Irisin has a connection to T2DM, with moderate performance in detection of micro-vascular complications. Irisin could, therefore, be used to early of diabetic microvascular complications in adult T2DM patients