Background : Mastalgia, or breast pain (or mastodynia), is globally a com‌mon symptom experienced by women of reproductive age; treatment for these conditions is not yet standardized. Most of the drugs used for mastalgia are expensive and have side effects, so, the aim of this study was to compare different agents for reducing mastalgia in fibrocystic disease of women in outpatient clinics at Zagazig University. Patients and methods: this prospective random comparative study has been carried out in zagazig university out patients clinics specifically in breast clinic subjects in period between may-2019 to mars -2020 on 68 patients enrolled with 3 months period of follow up. Results: In EPO group 30% of patients showed complete resolution and 61% showed partial response. The danazol group received, 58% of patients showed complete resolution and 41% showed partial improvement. In Tamoxifen group 47% of patients showed complete resolution while 52 % showed partial improvement. In the cabergoline group 14% of patient showed complete resolution and 42% showed partial improvement. Conclusion : Evening prime rose oil is effective in reducing the severity of mastalgia with minor tolerable side effects and should be used as first line of management. Danazol is the most effective agent but its side effects make it less favorable agent. Tamoxifen is the second most effective agent among the other agents with reversible tolerable side effects. cabergoline is significantly decrease breast pain especially cyclic mastalgia, with notable side effects.