Abstract
Background: Acne vulgaris is a multifactorial disease associated with pilosebaceous follicle,
Aim to measure serum IL-19 in different degrees of acne severity for better understanding of its role in the aetiopathogenesis of acne, Methods: Our study was a case control study which done at out-patient clinic of Dermatology, Venereology and Andrology Department at Zagazig University Hospitals. The study included 48 individual divided into 2 groups: Patient group: 36 patients with acne vulgaris (12 mild, 12 moderate, 12 severe) Control group: 12 healthy person.All subjects in this study were subjected to the following: history, Assessment of the severity of acne was done using acne staging and laboratory investigation (IL-19).Results: There was statistically significant difference in serum IL-19 between the different grades of the disease severity. Analysis revealed significant difference between IL-19 serum concentration between (mild and moderate group) and between (moderate and severe group), While highly significant difference was found between IL-19 serum concentration of mild cases group and severee cases group.Serum IL-19 level was not statistically related to neither the age of onset nor family history, gender, previous treatment.Conclusion: From this study we could prove that IL-19 is related to the inflammatory aetiopathogenesis of mild, moderate and severe acne vulgaris. Also Serum IL-19 level had significant statistical difference between the different grades of acne vulgaris severity.