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302187

The Relationship Between Post COVID-19 Rheumatological Manifestations and Angiotensin converting Enzyme 2 Level in Patients with Type 2 Diabetes

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Internal Medicine

Abstract

Background: Coronavirus disease (Covid-19) causes a systemic inflammatory syndrome with pulmonary involvement. Rheumatological involvement in patients with mild clinical forms of Covid-19 is uncertain. Diabetes mellitus (DM) is known to increase susceptibility to viral infections. Also, patients with DM have a reduced Angiotensin converting enzyme 2 (ACE2) expression that might contribute to the increased predisposition to severe lung injury. The aim of the work is to study the rheumatological manifestations with assessment of ACE2 level in post COVID patients with and without diabetes mellitus (DM).

Methods: We included a total of 160 consecutive patients in Covid-19 convalescent phase (after clinical recovery), all of them diagnosed with a positive PCR test. All participants were divided into two categories: 80 patients with COVID-19 and DM and another 80 patients with COVID-19 without DM. All patients subjected to history taking, clinical assessment, laboratory investigations (including serum ALT, AST, Albumin, Urea, Creatinine, FBG, HBA1c, Procalcitonin, CRP, Hemoglobin, WBC, Platelet count, Neutrophile count, Lymphocyte count, D-Dimer and ACE2).

Results: Patients with DM have a higher significant mean serum level of ACE2 (43.90 ± 20.04). Regarding post COVID rheumatological manifestation, patients with DM have a higher significant severity of arthralgia and arthritis with higher significant serum level of anti-nuclear antibody (ANA), rheumatoid factor (RF) and Anti-citrullinated protein (CCP) (p < 0.05).

Conclusion: We found that COVID-19 patients with D.M have a higher risk of rheumatological complications with higher level of ACE2 than COVID-19 patients without D.M.

DOI

10.21608/zumj.2023.210318.2801

Keywords

Angiotensin converting enzyme 2, Arthritis, COVID-19, Diabetes mellitus

Authors

First Name

Doaa

Last Name

Elgendy

MiddleName

Salah

Affiliation

Internal medicine department, faculty of medicine, Menoufia University, Menoufia, Egypt.

Email

doaa.algendy@med.menofia.edu.eg

City

Shebin el kom

Orcid

0000-0003-0954-6838

First Name

Bishoy

Last Name

Tawadros

MiddleName

Berzy

Affiliation

chest diseases and tuberculosis department, faculty of medicine, Menoufia university, Menoufia, Egypt.

Email

berzybishoy@gmail.com

City

Shebin El-kom

Orcid

-

First Name

Mostafa

Last Name

Mansour

MiddleName

Saieed

Affiliation

Anaesthesia, intensive care and pain medicine department, faculty of medicine, Menoufia university, Menoufia, Egypt.

Email

mostafa.said@med.menofia.edu.eg

City

Shebin El-kom

Orcid

0000-0003-1660-0476

First Name

Hytham

Last Name

Badr

MiddleName

Reda

Affiliation

Internal medicine department, faculty of medicine, Menoufia university, Menoufia, Egypt

Email

hythambadr87@yahoo.com

City

-

Orcid

0000-0002-6570-3941

Volume

30

Article Issue

1.3

Related Issue

47218

Issue Date

2024-04-01

Receive Date

2023-05-11

Publish Date

2024-04-01

Page Start

180

Page End

189

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_302187.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=302187

Order

22

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

The Relationship Between Post COVID-19 Rheumatological Manifestations and Angiotensin converting Enzyme 2 Level in Patients with Type 2 Diabetes

Details

Type

Article

Created At

30 Dec 2024