Beta
290704

Study of Urinary Angiotensinogen as an Indicator of Severity of Diabetic Nephropathy in Type 2 Diabetes

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Internal Medicine

Abstract

Background: Urinary angiotensinogen levels are higher in type 2 diabetes patients with nephropathy, a risk factor for developing renal and cardiovascular consequences. However, the potential relationship between serum urine angiotensinogen levels and albuminuria (in terms of its varying concentrations) is not yet established. As a result, we conduct this research. Method: Sixty-six adults with type 2 diabetes were split into three groups, each of which included 22 people based on their degree of albuminuria, in addition to an age- and gender-matched control group of 22 healthy volunteers. Routine laboratory tests and urine angiotensinogen were evaluated in the study groups and correlated to other study parameters. Results: The current study showed that urine angiotensinogen levels are more significant in diabetic patients with higher albuminuria levels, and it was also found to be associated with urinary albumin excretion in diabetic patients with different grades of albuminuria (n = 66, r = 0.666, p<0.001), and it had highly significant validity in the prediction of albuminuria among individuals with diabetes with sensitivity of 88.6%, specificity of 81.8% and accuracy of 86.4%. Conclusions: According to the findings of this study, increased urine angiotensinogen levels were associated with urinary albumin excretion, and elevated urinary angiotensinogen might be utilized as an effective marker for identifying the degree of albuminuria in diabetic individuals.

DOI

10.21608/zumj.2023.193114.2747

Keywords

albuminuria, angiotensinogen, Nephropathy, Diabetes mellitus

Authors

First Name

Usama

Last Name

Ragab

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

Email

usama.ragab.zu@gmail.com

City

Zagazig

Orcid

0000-0001-5411-1943

First Name

Yaser

Last Name

Elhendy

MiddleName

Abdel Monem

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

Email

yaserhendy@gmail.com

City

Zagazig

Orcid

-

First Name

Ghada

Last Name

Amr

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

ghada779@hotmail.com

City

Zagazig

Orcid

0000-0002-9327-7919

First Name

Ahmed

Last Name

Abdulsaboor

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

a.abdulsaboor@gmail.com

City

Zagazig

Orcid

0000-0002-8242-5285

First Name

Fady

Last Name

Labib

MiddleName

Atalah

Affiliation

Internal Medicine Department, Beala Central Hospital, Kafr Elshiekh, Egypt

Email

fadyatalah949@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

Noaman

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt

Email

anoaman@medicine.zu.edu.eg

City

Zagazig

Orcid

-

Volume

30

Article Issue

1.3

Related Issue

47218

Issue Date

2024-04-01

Receive Date

2023-02-11

Publish Date

2024-04-01

Page Start

162

Page End

171

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_290704.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=290704

Order

20

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Study of Urinary Angiotensinogen as an Indicator of Severity of Diabetic Nephropathy in Type 2 Diabetes

Details

Type

Article

Created At

30 Dec 2024