Background: It is unknown how thyroid hormones, TSH, and other elements of the metabolic syndrome are related to one another. It is possible to investigate and evaluate thyroid function in older adults with and without metabolic syndrome in order to draw attention to it and look for any connections between thyroid function and the elements of the metabolic syndrome.

Aim: To detect the association of thyroid Hormones, TSH and components of metabolic syndrome and to evaluate the relationship between thyroid Hormones, TSH and HOMA-IR.

Methods: This case-control study included 64 elderly subjects with and without metabolic syndrome recruited from outpatient of Zagazig University hospital, from July 2023 to January 2024. We divided the patients into group (I): 32 elderly healthy individuals without metabolic syndrome matched age and sex served as control group and group (II): 32 elderly patients with metabolic syndrome matched age and sex served as case group. Thyroid functions tests were measured.

Results: There was highly statistically significant increase in TSH in group II compared with group I (p≤0.001). There was statistically significant increase in FT3 in group II compared with group I (p≤0.05). There was statistically significant decrease in FT4 in group II compared with group I (p≤0.05) (Table 3).

Conclusion: In conclusion, metabolic syndrome is significantly associated with thyroid dysfunction with possible underlying mechanisms such as metabolic dysregulation.