Background: Sedation helps patients to tolerate uncomfortable gastrointestinal endoscopy procedures by relieving anxiety and pain. It decreases the risk of physical injury during gastrointestinal endoscopy procedures, also provides the endoscopist a good environment for an optimum examination. In addition, an appropriate level of sedation is necessary for safe procedures including therapeutic endoscopy. The goals of sedation are analgesia, amnesia, immobility during the procedure, ability to complete the procedure and quick patient recovery to pre-procedure level of consciousness. In recent years, the need to a safe and effective sedation has increased in practice. Therefore, new sedatives and analgesic drugs for optimal sedated endoscopy have recently emerged. This article reviews the characteristics of new innovations sedatives and analgesics drug, and describe their clinical use in gastrointestinal endoscopy.

Conclusion: Judicious use of sedation can alleviate the sympathetic response (rise in heart rate and systolic blood pressure) to the procedure. Midazolam and propofol are the most commonly used drugs in sedated endoscopy