Background: Sellar and suprasellar regions are complex areas of the brain, where different varieties of lesions can occur in this confined space. When evaluating sellar and suprasellar lesions prior to surgery, diffusion weighted MRI and MR spectroscopy are regarded as crucial diagnostic tools that supplement conventional MRI.

Aim of the Study: The aim of the recent study was to evaluate the role of the DWI and Single-Voxel 1H MRS Metabolites in characterization of Sellar and Suprasellar masses.

Methods: A prospective study has been conducted on 30 patients with various sellar and suprasellar masses consulted from Neurosurgery and Neurology Departments to the MRI unit over a period of 6 months between June 2023 and Nov 2023.They were examined with long-echo single voxel 1H -MRS and DWI by 1.5 Tesla clinical imaging machine. Examinations were guided by cMRI. We confirmed our diagnosis pathologically after surgical management.

Results: Sellar and suprasellar tumors exhibited variable values for diffusion and the mean ADC value was for macroadenoma is (0.72±0.25)x10-3 mm2/sec, craniopharyngeoma is (1.8±0.1)x10-3 mm2/sec, glioma is (1.38±0.5)x10-3 mm2/sec, germinoma (0.80±0.2)x10-3 mm2/sec and for meningioma is (0.94±0.16)x10-3 mm2/sec. Pituitary macroadenoma were typically characterized by Cr peak, moderate elevation of Cho peak and significant reduction of NAA,. Craniopharyngiomas were classically distinguished by notable reduction of all metabolites .Rise of Cho peak and decrease of NAA and Cr peaks typically characterize Gliomas. The most distinguishing metabolite of meningioma is Alanine.

Conclusions: Diffusion-weighted MRI and MR Spectroscopy can contribute to presurgical assessment and discrimination between various sellar, suprasellar masses.