Background: Psoriasis is a common skin disease associated with different co-morbidities. High serum levels of anti-tissue transglutaminase-2 IgA (TTG-IgA), produced and deposited in the intestine, characterizes celiac disease. Recently, an elevation in TTG-IgA antibodies in psoriatic cases was reported, compared to non-psoriatics.
Objective: The aim of the current study was to compare the level of anti-tissue transglutaminase IgA in psoriatic patients versus non-psoriatic control group and to find a possible relation with disease severity.
Methods: This was a case-control study conducted on 45 patients with psoriasis who attended the outpatient clinic of Dermatology, Andrology & STDs Department of Mansoura University Hospitals, and 45 age and sex matched completely healthy people.
Results: Psoriatic cases demonstrated a significant increase in TTG-IgA serum levels compared to non-psoriatic controls. GIT manifestations were prevalent among psoriatic cases and were related positively to the degree of psoriasis activity (PASI score). TTG-IgA concentration showed excellent value in differentiating psoriatic cases from controls. TTG-IgA demonstrated as a significant positive correlation with PASI score among psoriatic cases.
Conclusion: TTG-IgA concentration could be used as a significant predictor for psoriasis as well as its severity.