Background: Alopecia areata is a skin disease that causes partial or complete hair loss from the scalp and other parts of the body.
Objective: The current study aimed to determine genetic polymorphisms in PTPN22 in alopecia areata.
Subjects and methods: This study is a case-control study and randomized controlled clinical trial included (86) subjects who were categorized into two groups; group (1) with 43 healthy people acted as the control group. Group (2) with 43 patients diagnosed with alopecia areata. The polymerase chain reaction restriction fragment length polymorphism (PCR-RELP) analysis technique is used to determine the C1858T polymorphism in PTPN22 gene.
Results: The present study revealed that There was no remarkable variation between alopecia patients and healthy subjects regarding to age and gender. There was no significant difference between different PTPN22 C1858T genotypes among alopecia patients regarding to demographic data and clinical findings except family history. Concerning PTPN22 genotyping; CT, TT and CT+TT genotypes were significantly higher in cases compared to controls. Our study showed significant difference in dominant model CT + TT versus CC while showed an insignificant difference in recessive TT versus CC + CT between alopecia and healthy groups for PTPN22 C1858T polymorphism. there was statistically significant difference between cases and controls regarding to T allele distribution.
Conclusion:
Protein tyrosine phosphatase non receptor type 22 gene polymorphism is not excluded as a genetic cause of AA and showed good relation with family history.