Background: Hypercoagulable state is associated with thalassemic children with increased risk of thromboembolic events ,There are multiple factors are contributing to hypercoagulable state in thalassemia patient.
Aim of the study: To assesses the prothrombin G20210A gene polymorphism in Egyptian thalassemic children being additional risk factor for thromboembolism in thalssemic children .

Methods: This is a case control study. It included 40 thalassemic patients with thromboembolic manifistation and 40 healthy controls. The prothrombin gene polymorphism was identified using a restriction fragment length polymerase chain reaction (RFLP PCR).
Results: No Significant difference in prothrombin G20210A genotype between Thalssemic patient with thrombotic manifistation and controls regarding allele and genotype distributions. (OR 3.2 , 95 % CI 0.57–17.89 and p=0.082 for AA genotype ). A allele was significantly related to cases (25% in cases in comparison to 12.5% in controls).
Conclusion: prothrombin gene polymorphism has no role predisposition to thalassemic coagulability in thalassemic Egyptian children.