Background: Sepsis can range in severity from infection to septic shock, and it can result in multiple organ dysfunction syndrome (MODS) and death. Tenascins are extracellular matrix glycoproteins that are expressed during multicellular organism growth and are involved in a number of pathological processes including inflammation, tissue damage, tumor angiogenesis, and metastasis.
Objectives: The aim of this study is to investigate the relationship between serum Tenascin- C levels and sepsis and disease severity in Intensive Care Unit (ICU) patients .
Patients and methods: a case-control study, The selected participants included 9 apparently healthy subjects, 20 patients with sepsis in ICU, and 10 diseased patients without sepsis in ICU. All patients were subjected to full clinical assessments of patients by SOFA score and Lab tests : (CBC,PCT,CRP,LFT&KFT). Tenascin C was measured by ELISA for all participants.
Results: mean age for all groups is 21-70. There is a high significant rise in CRP,PCT,TLC, urea & creatinine, ALT and AST in septic patients in relation to that of nonseptic patients .haemoglobin and albumin level shows significant decrease in septic patients than that in non septic patients. Sensitivity of tenascin to predict cases with sepsis vs that without sepsis was 75% and specificity was 100% .
Conclusion: In septic patients, the level of serum Tenascin-C can help with early sepsis diagnosis and severity assessment.