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268942

The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Clinical Pathology

Abstract

Introduction:
As a major health problem, mortality due to sepsis accounts for about 42% in intensive care deaths. This high mortality rate necessitates rapid and accurate diagnosis of sepsis, differentiating it from other confusing conditions. Rapid and evidence-based management is expected to follow. The use of biomarkers gained high attention in the scientific community for sepsis diagnosis. In the current study, we aim to evaluate the diagnostic accuracy of measuring CRP, PCT and MR-proADM in differentiation between septic and non-septic patients within intensive care unit.
Methods:
A total of 64 subjects were enrolled. They were divided into: (1) control group: 32 Non-septic ICU patients, and (2) case group: 32 septic ICU patients. CBC, CRP, PCT, MR-proADM quantification was done at day 1 of sepsis suspension for case group and randomly for control group.
Results:
At a cut-off 78.479 pg/ml, MR-proADM has 93.8 % sensitivity, 90.6 % specificity, 90.9 % positive predictive value, 93.5% negative predictive value and 92.18 % accuracy.
Conclusion:
Based upon our findings, MR-proADM could be useful as a diagnostic marker in sepsis patients admitted to ICU. It had diagnostic criteria comparable to that of PCT and better than that of CRP.
Key words:
Sepsis, ICU, MR-proADM, CRP, PCT

DOI

10.21608/zumj.2022.167791.2659

Keywords

Sepsis, ICU, MR-proADM, CRP, PCT

Authors

First Name

Alaa

Last Name

Fahmy

MiddleName

-

Affiliation

Ministry of Health, Egypt.

Email

lulufahmy88@gmail.com

City

-

Orcid

0000-0002-3846-202X

First Name

Mervat

Last Name

Azab

MiddleName

M.

Affiliation

Department of clinical pathology, Faculty of Medicine, Zagazig University, Egypt.

Email

mervatazab2022@yahoo.com

City

-

Orcid

0000-0002-1055-044X

First Name

Ghada

Last Name

E. Amr

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine – Zagazig University, Egypt

Email

ghada779@hotmail.com

City

-

Orcid

0000-0002-9327-7919

First Name

heba

Last Name

Helmy

MiddleName

-

Affiliation

Associate Professor of Anesthesiology and surgical intensive care, Faculty of Medicine, Zagazig University, Egypt

Email

hebamatar@yahoo.com

City

zagazig

Orcid

0000-0003-3539-4364

First Name

Amany

Last Name

Sediq

MiddleName

-

Affiliation

Department of clinical pathology, Faculty of Medicine, Zagazig University, Egypt

Email

amany_mohy2006@yahoo.com

City

-

Orcid

0000-0003-1371-2595

Volume

29

Article Issue

5

Related Issue

43252

Issue Date

2023-09-01

Receive Date

2022-10-10

Publish Date

2023-09-01

Page Start

1,294

Page End

1,298

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_268942.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=268942

Order

10

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

The role of mid-regional proadrenomedullin in diagnosis of sepsis in intensive care unit patients

Details

Type

Article

Created At

30 Dec 2024